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When Dr. K.G. Bode introduced endoscopic retrograde cholangiography (ERC) in 1973, he believed that the procedure could provide an effective minimally invasive means of performing diagnostic and therapeutic cholangiography in patients with biliary tract disease. The ERC was not particularly useful for performing therapeutic interventions and was plagued by concerns about the introduction of dilating catheters and guide wires into the biliary tree. Furthermore, the procedure was rendered less successful because of the appearance of a 0.035″ hydrophilic transparent needle during introduction of the balloon distal tip of the catheter into the duodenum. Its commercial appeal was limited to patients with known or suspected biliary tract disease. Recently, a new generation of indwelling endoscopic balloons and proton pump inhibitors, has redefined the role of ERC. Recently developed balloon catheters are smaller, more flexible and resistant to pressure. Durable colonic catheters, the introduction of proton pump inhibitors and less dense filling fluids permit rapid development of new forms of endoscopic therapy.ABSTRACT There are many approaches to drug discovery in cancer. Each of these approaches highlights different aspects of the biology of the disease and/or the patient. Yet no single approach can overcome the problems of allogeneic immunosuppression and lack of antigen presenting cells that cause drug resistance and immunosuppression. The goal of this project is to apply