The Mash Up Mix 2006 Torrent ((TOP))
The Mash Up Mix 2006 Torrent
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The effects of dopamine (DA), serotonin (5HT) and 5-hydroxytryptamine (5-HT) were studied in the anticonvulsant activity of the enantiomer (+)-7-hydroxy-2-methyl-1-phenylcycloprop[b]azepine (7-OH-PCEB) and its two (R,R)- and (S,S)-diastereomers. Pretreatment with 3 mg/kg 7-OH-PCEB (R,R)- and (S,S)-diastereomers as well as with 7-OH-PCEB was ineffective while pretreatment with 1 mg/kg (R,R)- and (S,S)-diastereomers produced good anticonvulsant activity against MES and PTZ-induced seizures in the mice. Pretreatment with 3 mg/kg (R,R)- and (S,S)-diastereomers either decreased or did not change the brain concentration of (R,R)-diastereomer and produced anticonvulsant activity against MES. In contrast, pretreatment with 3 mg/kg (S,S)-diastereomer markedly increased the brain concentration of (R,R)-diastereomer and produced anticonvulsant activity against MES. Pretreatment with 3 mg/kg of DA and 5HT enhanced the anticonvulsant activity of (R,R)-diastereomer, whereas pretreatment with 3 mg/kg of 5-HT had no effect on the anticonvulsant activity of (S,S)-diastereomer. The results suggest that the increased anticonvulsant activity of (S,S)-diastereomer after pretreatment with 3 mg/kg 5-HT was due to the synergistic action of 5-HT with (R,R)-
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